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 Disseny de Sistemes Biològics
Cap de Grup:



1981 Biology Sciences, Universidad Complutense de Madrid (Spain)
1982 Master of Sciences, Universidad Complutense de Madrid (Spain).
1985 Ph.D. in Biochemistry, Universidad Complutense de Madrid (Spain).
1987 Postdoctoral, Center of Mollecuar Biology (CSIC-UAM), Universidad Autónoma de Madrid (Spain).
1991 Postdoctoral, Cambridge University (Great Britain).
2001 present Head of Dpt., Dpt. Structural & Computational Biology, EMBL (Germany).
2005 present ICREA Professor and Group Leader at the Center for Genomic Regulation, Barcelona (Spain).

Més ...

Sumari

In our group we are aiming at a quantitative understanding of biological systems to an extent that one is able to predict systemic features and with the hope to rational design and modify their behaviour.  This applies to any system comprising biological components that is more than the mere sum of its components, or, in other words, the addition of the individual components results in systemic properties that could not be predicted by considering the components individually.  By achieving this objective we are aiming at new global understanding and treatment of human diseases in which the target will not be a single molecule but a network.  For this purpose in our group we develop on one hand new software and theoretical approximations to understand complex systems and on the other we do experiments to validate our predictions.

You can find more information about our group and our research project on our website http://serrano.crg.es


Última modificació: 28/03/2008


Línies d'Investigació
Publicacions seleccionades

Güell M, Van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, et al.
Transcriptome Complexity in a Genome-Reduced Bacterium
Science 326(5957):1268-71 (2009). PubMed ID: 19965477.abstract
Kühner S, Van Noort V, Betts MJ, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castaño-Diez D, Chen WH, Devos D, et al.
Proteome Organization in a Genome-Reduced Bacterium
Science 326(5957):1235-40 (2009). PubMed ID: 19965468.abstract
Yus E, Maier T, Michalodimitrakis K, Van Noort V, Yamada T, Chen WH, Wodke JAH, Güell M, Martínez S, Bourgeois R, Kühner S, Raineri E, Letunic I, et al.
Impact of Genome Reduction on Bacterial Metabolism and Its Regulation
Science 326(5957):1263-8 (2009). PubMed ID: 19965476.abstract
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L.
Evolvability and hierarchy in rewired bacterial gene networks
Nature 452(7189):840-5 (2008). PubMed ID: 18421347.abstract
Alibés A, Nadra AD, De Masi F, Bulyk ML, Serrano L, Stricher F.
Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example
Nucleic Acids Res [Epub ahead of print] (2010). PubMed ID: 20685816.

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Disseny de Sistemes Biològics