Our main goal is to identify new mRNAs that are translationally regulated by cytoplasmic polyadenylation during the meiotic progression and the early embryonic mitosis. We will also attempt to elucidate the molecular mechanism(s) that regulate the sequencial activation of the stored maternal mRNAs during the cell cycle progression. To accomplish this goal we will analyze the cis-acting elements present in the mRNAs that are activated at different times during the meiotic progression and the early embryonic mitosis. We will also characterize the trans-acting proteins that are recruited to the 3´-UTR(s) of the regulated mRNAs and determine how those proteins interact with the translation initiation factors that recruit the 40S ribosomal subunit to the 5´-end of the mRNA.