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Research

Evolutionary Genomics

Group Leader:



icrea
2012                HHMI International Early Career
2011                 ICREA Research Professor
2008-                Group leader at the Bioinformatics
                         & Genomics Programme, CRG,
                         Barcelona, Spain
2005-2008        PhD degree in Biology from UC
                         San Diego
2003-2004        Master of Arts degree in Population
                         Biology from UC Davis
2000-2003        Research Scientist, NCBI, NIH
1996-2000        Bachelor of Arts degree in Biology
                         and Ecology from Simon's Rock
                         College

Summary

We strive to create an open environment for inquiry of many different questions in different areas of biology and evolution. Currently, we are focused on computational studies of genomic information including sequences, expression data, protein and RNA structures, genetic and protein networks. We analyze these data under the prism of population genetics and evolutionary theory to describe novel evolutionary and biological phenomena. In short, we use any data that we can get our hand on to understand something new about evolution and biology. We have several fruitful collaborations with experimental groups working on specific genes or phyla and we are also pursuing simple experimental projects in support of our computational inquiries.

Research Lines
Selected Publications

Assis R, Kondrashov AS, Koonin EV, Kondrashov FA..
"Nested genes and increasing organizational complexity of metazoan genomes"
Trends Genet 2008 Oct;24(10):475-8 (2008).
Kern AD, Kondrashov FA..
Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs.
Nat Genet. 2004 Nov;36(11):1207-12 (2004). abstract
Kondrashov FA, Koonin EV..
"A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications"
Trends Genet. 2004 Jul;20(7):287-90. Review (2004).
Kondrashov AS, Sunyaev S, Kondrashov FA..
"Dobzhansky-Muller incompatibilities in protein evolution."
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14878-83. (2002). abstract
Kondrashov FA, Rogozin IB, Wolf YI, Koonin EV..
"Selection in the evolution of gene duplications"
Genome Biol. 2002;3(2): (2002). abstract

 
 
 

Group Members